- Location
- Deep South of Cambridgeshire
If it's so mild, why are there already Omicron cases in hospital?
If it's so mild, why are there already Omicron cases in hospital?
Depends on the definition of "mild", perhaps? Mild might mean anything short of requiring ventilation. Just guessing.
We'll see UK-specific data soon enough. If it does end up being universally "mild" by that definition I'm sure we'll all be delighted.
I’m definitely in favour of mild variants but to @Dan Baillie ’s point - surely precautions are wise at this stage. And we should remember - we are still at a somewhat stable ~120 deaths per day in the UK. This makes covid over twenty times deadlier than motor vehicles. If Omicron significantly *reduces* the total deaths - well, that would be awesome, but I don’t think we can confidently state that that is going to happen can we?
That must have been Gove's 'very challenging information.'A summary of where things stand. Explains why the govt is reacting in the way it is and why everyone should be so concerned until we know for sure whether this variant is more or less severe...
"Real world data confirm Omicron escape from Pfizer and AstraZeneca vaccines. However, preliminary real world data from the UK’s Health Security Agency suggests that overall vaccine efficacy mirrors antibody responses. The preliminary data contained in its Technical Briefing 31 published on 10 December showed that efficacy of the 2-dose PFE vaccine against the Delta COVID-19 variant fell from c.90% at 2-9 weeks after the second vaccine dose to c. 60% at 6 weeks. The efficacy against the Omicron variant at six weeks was in the mid-30s % range, so almost half as effective as against the Delta variant. The data also show, with caveats, that the efficacy of the AZN vaccine against the Delta variant fell from the high-70s % at 2-9 weeks post the second dose to 40% at six weeks post the second dose. However, the efficacy against the Omicron variant was just above zero at 6 weeks. The caveats on the data with the AZN vaccine are that low numbers of patients overall and a high proportion of elderly patients could have skewed the data, but when vaccine efficacy was starting at a lower level, we believe a greater reduction in efficacy against the Omicron strain makes sense scientifically. Countries that have used the AZN vaccine as the primary vaccine source are arguably more exposed to lower efficacy against Omicron if these data are validated. The Pfizer/BioNTech vaccine as a third dose/booster seems to do its job…for now. On a positive note, real world protection versus Omicron was boosted to 71-76% (source: UKHSA) after the PFE/BNTX vaccine was given as a third/booster dose, whether the PFE/BNTX or AZN vaccine was given as the first two doses. But, these data are limited in sample size. What is clearly not known yet is the duration of protection from the third/booster vaccine dose, given that protection against the Delta variant declined by around 50% from 4 months after the second dose. Scientifically, against a more infectious variant, at best, the same rate of decline in efficacy may be expected, but a more rapid decline would not be a surprise, requiring new Omicron specific vaccines."
Bryan,I'm not sure how much I buy this argument. Presumably the "out-competing" argument only works if the human immune system reacts very similarly to the two variants. If they are too dissimilar, as may be implied by talk of "vaccine escape" etc, then presumably there's no reason why the two variants can't just spread independently? To take an extreme example, having influenza doesn't stop you catching measles...
How about hospitalisations?It is certainly grounds for hope that whilst cases have shot up in South Africa, with Omicron having reached 80% of cases by November 20, deaths there have not, so far, risen.
Hi Po, sorry if I've missed something in a previous post but which report are you referring to?
Might the relative youthfulness of the population be part of this?It is certainly grounds for hope that whilst cases have shot up in South Africa, with Omicron having reached 80% of cases by November 20, deaths there have not, so far, risen.
Might the relative youthfulness of the population be part of this?
There was a time (well, actually multiple times) I wanted to go back to the old covid thread (now in political forum) to summarise what did certain people vigorously argue all along these two years, or to be fairer, to list what did I say right and wrong, and what some others did. I gave up the idea because, first of all, that would be really time consuming, secondly it can be a little bit ungracious to some forum members, even I personally never had the pleasure to share a drink with them. Plus those certain people probably won't feel that I am fair anyway, they might think I am too much lean towards the "science and medical opinions" side (that's what I heard from a certain party MP said on national TV: he thinks "the government is giving too much ground to science and medical opinions", not sure what does that mean).I'm surprised you're looking to get into a competition about who's made the best predictions so far!
But equally a higher prior spread of covid apparently. Regardless, we simply don't have the hard data yet in any reliable form with which to assess how mild/severe omicron is. What we do know for sure is that it is massively more infectious and that the majority of our population has zero vaccine protection. I see no way that any responsible govt couldn't be taking at least the measures the UK has instituted and praying that the booster programme can be delivered quickly enough to forestall the inevitable explosion of cases until we're sure it's just a mild illness.But then much lower vax rates. So hard to compare.
In light of the data Dan quoted on vax benefit declining to zero maybe that's not as big a factor as we'd like it to be.But then much lower vax rates. So hard to compare.
It depends on whether your opinions are based on your interpretations of the facts available at the time, or on beliefs (beliefs by definition being things you hold to be true without any supporting evidence).I've never quite understood why so many people are really defensive about being wrong (not in this or any other thread, just generally.) I'm wrong all the time, and will happily hold my hand up and admit to it.
No you're not!I'm wrong all the time, and will happily hold my hand up and admit to it.
Could be! Observational data could be explained by any number of confounders. The lack of a rise in deaths there so far certainly isn't conclusive. It's an unreliable sign. But still a more cheerful one than the presence of a rise!Might the relative youthfulness of the population be part of this?
I've never quite understood why so many people are really defensive about being wrong (not in this or any other thread, just generally.) I'm wrong all the time, and will happily hold my hand up and admit to it.
About this part, with respect, you can't have evidence to prove (or disprove) a counterfactual, that's the point.With reference to Po’s post my comment was slightly tongue in cheek although I do still believe that we would be in a far better position now without any restrictions being implemented at all. I accept that’s a minority view on here but I haven’t seen any evidence to the contrary.
I think Vallance said something along the lines that 20k deaths would be a relatively good outcome. I didn't take 20k to be his base case and I guess he might not have been surprised to see it nudging 150k now.About this part, with respect, you can't have evidence to prove (or disprove) a counterfactual, that's the point.
As for predictions, indeed Vallance said early on he thought there might be 20,000 deaths. He was wrong about that one, too. The models that were so wildly wrong were for what would happen IN THE ABSENCE of restrictions. And guess what happens when restrictions were introduced?
It is genuinely fascinating to me the biases on both directions (I freely accept I have them too) that make me listen to Neil Ferguson and think 'entirely responsible serious person acting in the best interests of the country and fully aware of the weaknesses in his method' and others think 'Dr. Doom'...
I'm feeling a bit left out since my booster was Moderna (presumably half dose) and nobody is yet talking about its effectiveness against Omicron. The data above suggests my two AZs, the last almost 7 months ago, are not providing much protection, so I hope Moderna is.