NWR new zero tolerance covid thread

Depends on the definition of "mild", perhaps? Mild might mean anything short of requiring ventilation. Just guessing.

We'll see UK-specific data soon enough. If it does end up being universally "mild" by that definition I'm sure we'll all be delighted.

From the interview Bryan, she is saying a 5 day illness that hasn’t required any hospitalisations for anybody regardless of vacccination status or comorbities. Now there will be some exceptions of course but if that is the general pattern then it’s very good news.
 
I’m definitely in favour of mild variants but to @Dan Baillie ’s point - surely precautions are wise at this stage. And we should remember - we are still at a somewhat stable ~120 deaths per day in the UK. This makes covid over twenty times deadlier than motor vehicles. If Omicron significantly *reduces* the total deaths - well, that would be awesome, but I don’t think we can confidently state that that is going to happen can we?
 
I’m definitely in favour of mild variants but to @Dan Baillie ’s point - surely precautions are wise at this stage. And we should remember - we are still at a somewhat stable ~120 deaths per day in the UK. This makes covid over twenty times deadlier than motor vehicles. If Omicron significantly *reduces* the total deaths - well, that would be awesome, but I don’t think we can confidently state that that is going to happen can we?

In a funny kind of way we could be costing lives by not allowing Omicron to spread quickly. If it’s much milder than Delta then the quicker it becomes the dominant strain the better. I realise it’s early days but the South Africans have not increased their threat levels and their data is very promising.
 
A summary of where things stand. Explains why the govt is reacting in the way it is and why everyone should be so concerned until we know for sure whether this variant is more or less severe...

"Real world data confirm Omicron escape from Pfizer and AstraZeneca vaccines. However, preliminary real world data from the UK’s Health Security Agency suggests that overall vaccine efficacy mirrors antibody responses. The preliminary data contained in its Technical Briefing 31 published on 10 December showed that efficacy of the 2-dose PFE vaccine against the Delta COVID-19 variant fell from c.90% at 2-9 weeks after the second vaccine dose to c. 60% at 6 weeks. The efficacy against the Omicron variant at six weeks was in the mid-30s % range, so almost half as effective as against the Delta variant. The data also show, with caveats, that the efficacy of the AZN vaccine against the Delta variant fell from the high-70s % at 2-9 weeks post the second dose to 40% at six weeks post the second dose. However, the efficacy against the Omicron variant was just above zero at 6 weeks. The caveats on the data with the AZN vaccine are that low numbers of patients overall and a high proportion of elderly patients could have skewed the data, but when vaccine efficacy was starting at a lower level, we believe a greater reduction in efficacy against the Omicron strain makes sense scientifically. Countries that have used the AZN vaccine as the primary vaccine source are arguably more exposed to lower efficacy against Omicron if these data are validated. The Pfizer/BioNTech vaccine as a third dose/booster seems to do its job…for now. On a positive note, real world protection versus Omicron was boosted to 71-76% (source: UKHSA) after the PFE/BNTX vaccine was given as a third/booster dose, whether the PFE/BNTX or AZN vaccine was given as the first two doses. But, these data are limited in sample size. What is clearly not known yet is the duration of protection from the third/booster vaccine dose, given that protection against the Delta variant declined by around 50% from 4 months after the second dose. Scientifically, against a more infectious variant, at best, the same rate of decline in efficacy may be expected, but a more rapid decline would not be a surprise, requiring new Omicron specific vaccines."
That must have been Gove's 'very challenging information.'
 
I'm not sure how much I buy this argument. Presumably the "out-competing" argument only works if the human immune system reacts very similarly to the two variants. If they are too dissimilar, as may be implied by talk of "vaccine escape" etc, then presumably there's no reason why the two variants can't just spread independently? To take an extreme example, having influenza doesn't stop you catching measles...
Bryan,

The data from SA suggests that it replaces it.

I saw a report last week that stated that it was already at 99%. Will try and dig it out.
 
Hi Po, sorry if I've missed something in a previous post but which report are you referring to?
More details as quoted by George and Dan, basically saying that the protection two doses AZ gave is statistically insignificant against Omicron infection.

Luckily I booked my Sunday jab on Thursday when there were plenty of places, I guess since people saw this on Friday those slots were quickly taken + lots of walk-in.

I think that‘s sensible reaction rather than toilet-roll style panic. I trust that two doses can still protect me somehow from severe illness (how much we don‘t know) and I hope it is true that Omicron gives less severe illness. But nobody wants to get it at all at any time, let alone before Christmas! See how many people in this forum suffer smell and taste loss, and can you imagine how disturbing it will be to be tested positive during Christmas, mild symptom or not.
 
I'm feeling a bit left out since my booster was Moderna (presumably half dose) and nobody is yet talking about its effectiveness against Omicron. The data above suggests my two AZs, the last almost 7 months ago, are not providing much protection, so I hope Moderna is.
 
I'm surprised you're looking to get into a competition about who's made the best predictions so far!
There was a time (well, actually multiple times) I wanted to go back to the old covid thread (now in political forum) to summarise what did certain people vigorously argue all along these two years, or to be fairer, to list what did I say right and wrong, and what some others did. I gave up the idea because, first of all, that would be really time consuming, secondly it can be a little bit ungracious to some forum members, even I personally never had the pleasure to share a drink with them. Plus those certain people probably won't feel that I am fair anyway, they might think I am too much lean towards the "science and medical opinions" side (that's what I heard from a certain party MP said on national TV: he thinks "the government is giving too much ground to science and medical opinions", not sure what does that mean).

Still, it's rather amusing to see some of them say that they are perfectly happy about some gravely wrong "predictions". I guess even I spend my Christmas holiday reviewing what was said, people would still deny.
 
But then much lower vax rates. So hard to compare.
But equally a higher prior spread of covid apparently. Regardless, we simply don't have the hard data yet in any reliable form with which to assess how mild/severe omicron is. What we do know for sure is that it is massively more infectious and that the majority of our population has zero vaccine protection. I see no way that any responsible govt couldn't be taking at least the measures the UK has instituted and praying that the booster programme can be delivered quickly enough to forestall the inevitable explosion of cases until we're sure it's just a mild illness.
 
I've never quite understood why so many people are really defensive about being wrong (not in this or any other thread, just generally.) I'm wrong all the time, and will happily hold my hand up and admit to it.
It depends on whether your opinions are based on your interpretations of the facts available at the time, or on beliefs (beliefs by definition being things you hold to be true without any supporting evidence).
 
I've never quite understood why so many people are really defensive about being wrong (not in this or any other thread, just generally.) I'm wrong all the time, and will happily hold my hand up and admit to it.

With reference to Po’s post my comment was slightly tongue in cheek although I do still believe that we would be in a far better position now without any restrictions being implemented at all. I accept that’s a minority view on here but I haven’t seen any evidence to the contrary.

The main problem for me is not that people have been wrong, that’s inevitable, it’s that the government’s advisors’ forecasts have been wildly inaccurate at every stage - not slightly wrong but out by miles. And yet they have continued to base their policy decisions on that advice. July was the only time they seemed to deviate from the scientists’ predictions and the scientists were proved wrong again. Even now they are talking up the potential for a million cases per day, and scaremongering about Omicron when the South African data does not support it. Boris Johnson now talking about the first death “with” Omicron - it’s irresponsible scaremongering. What did the person actually die ‘from’? It’s an attempt to create hysteria and Covid has become a form of neurosis for the UK government and public.

The country has been fed a diet of fear and many people have succumbed.
 
With reference to Po’s post my comment was slightly tongue in cheek although I do still believe that we would be in a far better position now without any restrictions being implemented at all. I accept that’s a minority view on here but I haven’t seen any evidence to the contrary.
About this part, with respect, you can't have evidence to prove (or disprove) a counterfactual, that's the point.

As for predictions, indeed Vallance said early on he thought there might be 20,000 deaths. He was wrong about that one, too. The models that were so wildly wrong were for what would happen IN THE ABSENCE of restrictions. And guess what happens when restrictions were introduced?

It is genuinely fascinating to me the biases on both directions (I freely accept I have them too) that make me listen to Neil Ferguson and think 'entirely responsible serious person acting in the best interests of the country and fully aware of the weaknesses in his method' and others think 'Dr. Doom'...
 
About this part, with respect, you can't have evidence to prove (or disprove) a counterfactual, that's the point.

As for predictions, indeed Vallance said early on he thought there might be 20,000 deaths. He was wrong about that one, too. The models that were so wildly wrong were for what would happen IN THE ABSENCE of restrictions. And guess what happens when restrictions were introduced?

It is genuinely fascinating to me the biases on both directions (I freely accept I have them too) that make me listen to Neil Ferguson and think 'entirely responsible serious person acting in the best interests of the country and fully aware of the weaknesses in his method' and others think 'Dr. Doom'...
I think Vallance said something along the lines that 20k deaths would be a relatively good outcome. I didn't take 20k to be his base case and I guess he might not have been surprised to see it nudging 150k now.
 
I'm feeling a bit left out since my booster was Moderna (presumably half dose) and nobody is yet talking about its effectiveness against Omicron. The data above suggests my two AZs, the last almost 7 months ago, are not providing much protection, so I hope Moderna is.

I had 2 x Moderna and also regret the paucity of UK-based data on this particular vaccine. Most HMG info rather unsatisfactorily lumps Pfizer/Moderna together even though they appear to be different in many regards. There is separate guidance offered for each where it has been used more commonly e.g. in the US.

I fully intend to get my booster ASAP but Moderna officially recommends a minimum interval of 6 months after the second dose, which would mean waiting until March 2022 in my case, and thus no doubt incurring Sajid's displeasure.

Genuinely not sure how to play this one and am interested to hear from anyone else who had Moderna. It's all they were offering the U-40s at one point so there must be plenty of ppl having a similar conversation.
 
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